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In these circumstances, it isoften dif?cult or impossible to invasively venti-late the patient as effectively as when they arebreathing spontaneously, even in the setting ofimpending respiratory failure.

Sampath J Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP, SchuetzJD (2001) Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 notMRP1. Although the majority of mutant p53 studiessuggest that the presence of mutant p53 reduces sensitivity to chemotherapy orradiation, there are many studies that show no effect or show the opposite effect;that is, that mutant p53 enhances sensitivity to these agents. Reports that she is able to perform ADLsindependently

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A common method for reducing extraneous variable differences is tomatch the various groups on the extraneous variables known to be most highly correlatedwith the dependent variable. Thesesubjects react similarly to chemically diverseNSAIDs, ruling out immunological basis for thereaction

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